Braithwaite S S, Bitterman P, DeGeest K, Lebbin D R
Department of Endocrinology, Luther Midelfort Mayo Health System, Eau Claire, Wisconsin 54702-4105, USA.
Endocr Pract. 2001 Jan-Feb;7(1):40-3. doi: 10.4158/EP.7.1.40.
To report a case of virilizing ovarian hilus cell hyperplasia detected postmenopausally in association with a simple cyst and to review the related literature, including four similar cases.
Hormonal and pathologic studies were conducted, and ovarian venous catheterization was performed during total abdominal hysterectomy.
In our 69-year-old female patient, serum testosterone levels were 508, >3,200, and 11 ng/dL, respectively, in peripheral blood preoperatively, in ovarian venous blood obtained intraoperatively, and in peripheral blood postoperatively. The wall of the cyst contained several clusters of hilus cells, which were also found asymmetrically lateralized to the affected ovary.
Hilus cell hyperplasia should be suspected in any case of postmenopausal virilization in which ultrasonography or magnetic resonance imaging suggests the presence of a simple ovarian cyst.
报告一例绝经后发现的伴有单纯囊肿的男性化卵巢门细胞增生病例，并复习相关文献，包括4例类似病例。
进行了激素和病理研究，并在全腹子宫切除术中进行了卵巢静脉插管。
在我们69岁的女性患者中，术前外周血、术中获得的卵巢静脉血及术后外周血中的血清睾酮水平分别为508、>3200和11 ng/dL。囊肿壁包含几簇门细胞，也不对称地偏向患侧卵巢。
对于任何绝经后男性化且超声或磁共振成像提示存在单纯卵巢囊肿的病例，均应怀疑有门细胞增生。
