维生素E对体外人精子活力和脂质过氧化的影响。
Effect of vitamin E on human sperm motility and lipid peroxidation in vitro.
作者信息
Verma A, Kanwar K C
机构信息
Department of Biophysics, Panjab University, Chandigarh 160014, India.
出版信息
Asian J Androl. 1999 Sep;1(3):151-4.
AIM
To assess the protective efficacy of vitamin E to counteract the reactive oxygen species (ROS) mediated damage on sperm motility, viability and lipid peroxidation.
METHODS
Human semen samples were obtained from the local hospital. The split seminal fractions freed of seminal plasma were reconstituted in Ringer-Tyrode and subjected to varied vitamin E concentrations (0.1-2 mmol/L).
RESULTS
Dose-dependent improvement in both motility and viability accompanied by concomitant decrease in malondialdehyde (MDA--an end product of lipid peroxidation) following vitamin E supplementation was noticed.
CONCLUSION
Vitamin E protects against the ROS mediated damage on spermatozoa. Vitamin E supplementation could be of clinical importance for prolonged spermatozoal storage whenever needed.
目的
评估维生素E对抗活性氧（ROS）介导的对精子活力、生存能力及脂质过氧化损伤的保护功效。
方法
从当地医院获取人类精液样本。去除精浆后的精液部分在林格-台氏液中重悬，并给予不同浓度的维生素E（0.1 - 2 mmol/L）。
结果
补充维生素E后，精子活力和生存能力呈剂量依赖性提高，同时丙二醛（MDA，脂质过氧化的终产物）含量降低。
结论
维生素E可保护精子免受ROS介导的损伤。在需要延长精子储存时间时，补充维生素E可能具有临床重要性。
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