精索静脉曲张患者血浆内皮素变化的研究。
Studies on plasma endothelin changes in varicocele patients.
作者信息
Xu Q Q, Zhu J C, Jiang H, Wang X F, Hou S K, Liu Q L
机构信息
Department of Urology, People's Hospital, Beijing Medical University, Beijing 100011, China.
出版信息
Asian J Androl. 1999 Sep;1(3):159-60.
AIM
To investigate the possible role endothelin may play in the pathogenesis of varicocele and varicocele-induced infertility.
METHODS
In varicocele patients, radioimmunoassay is used to determine the blood endothelin concentration in the spermatic vein and the antecubital vein separately.
RESULTS
The blood endothelin concentration of the spermatic vein (66.8 +/- 23.5 pg/mL) was significantly higher (P < 0.05) than that of the antecubital vein (55.3 +/- 25.3 pg/mL). The endothelin concentration in the spermatic vein in Grade II varicocele patients was not significantly different from that in Grade III patients (P = 0.87).
CONCLUSION
The higher blood endothelin level in the spermatic vein may indicate the involvement of endothelin in the pathophysiology of varicocele and varicocele-induced infertility.
目的
探讨内皮素在精索静脉曲张及其所致不育症发病机制中可能发挥的作用。
方法
对精索静脉曲张患者，采用放射免疫分析法分别测定其精索静脉和肘前静脉血中内皮素浓度。
结果
精索静脉血中内皮素浓度（66.8±23.5 pg/mL）显著高于肘前静脉血中内皮素浓度（55.3±25.3 pg/mL，P<0.05）。Ⅱ级精索静脉曲张患者精索静脉内内皮素浓度与Ⅲ级患者相比，差异无统计学意义（P=0.87）。
结论
精索静脉血中较高的内皮素水平可能提示内皮素参与了精索静脉曲张及其所致不育症的病理生理过程。
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