Ito H, Fuse H, Minagawa H, Kawamura K, Murakami M, Shimazaki J
Fertil Steril. 1982 Feb;37(2):218-22. doi: 10.1016/s0015-0282(16)46043-7.
Blood was collected from 20 patients with varicocele (15 in the infertile group and 5 in the incidental varicocele group) at the time of high ligation by insertion of a catheter into the internal spermatic vein toward the renal side. Simultaneously, blood was obtained from the antecubital vein. The levels of cortisol, prostaglandin (PG)(A + B), PGE, and PGF in these blood samples were measured. Although no differences in cortisol and PG(A + B) levels were observed between internal spermatic and peripheral vein bloods in varicocele patients examined, PGE and PGF levels were higher in internal spermatic venous bloods than in peripheral venous bloods. Differences in PGF levels between the samples of blood from the internal spermatic vein and from the peripheral vein in cases of the infertile group were larger than those of the incidental varicocele group. PGE and PGF in internal spermatic vein blood samples were correlated. The possibility that PGE and PGF, refluxed from the renal vein to the testes via the internal spermatic vein in varicocele patients, disturbs spermatogenesis is discussed.
在对20例精索静脉曲张患者（15例为不育组，5例为偶然发现精索静脉曲张组）进行高位结扎时，通过将导管插入精索内静脉并朝向肾侧来采集血液。同时，从前臂静脉采集血液。测量这些血样中皮质醇、前列腺素（PG）（A+B）、PGE和PGF的水平。虽然在所检查的精索静脉曲张患者中，未观察到精索内静脉血与外周静脉血之间皮质醇和PG（A+B）水平的差异，但精索内静脉血中PGE和PGF水平高于外周静脉血。不育组精索内静脉血样与外周静脉血样之间PGF水平的差异大于偶然发现精索静脉曲张组。精索内静脉血样中的PGE和PGF具有相关性。讨论了精索静脉曲张患者中PGE和PGF经精索内静脉从肾静脉反流至睾丸从而干扰精子发生的可能性。
