女贞子果实提取物对实验性糖尿病大鼠生殖功能的影响。
Effect of ligustrum fruit extract on reproduction in experimental diabetic rats.
作者信息
Feng S L, Li S H, Wang Y, Chen C C, Gao B
机构信息
Liaoning Provincial Diabetes Treatment Center, Shenyang, China.
出版信息
Asian J Androl. 2001 Mar;3(1):71-3.
AIM
To study the effect of ligustrum fruit on spermatogenesis and blood gonadal hormones in diabetic rats.
METHODS
Experimental diabetes was induced in male Wistar rats with streptozotocin. Ligustrum fruit extract was given by gastric gavage at a dose of crude drug 30 g x kg(-1) x d(-1) for 110 days. The serum gonadadotropic hormones and testosterone were determined on d 60 and testicular histology examined on d 110.
RESULTS
In the control diabetic rats, the seminiferous tubules were dilated and the spermatogenic cells irregularly arranged. Spermatogenesis was arrested with the number of spermatids highly reduced and spermatozoa not observed. In the treated rats, all types of spermatogenic cells were practically normal. The serum luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels were higher in the treated than in the control rats, but the difference was insignificant.
CONCLUSION
In experimental diabetic rats, ligustrum fruit extract protects the damaging effect of experimental diabetes on spermatogenesis.
目的
研究女贞子对糖尿病大鼠精子发生及血性腺激素的影响。
方法
用链脲佐菌素诱导雄性Wistar大鼠患实验性糖尿病。以30 g·kg⁻¹·d⁻¹的生药剂量通过胃管给予女贞子提取物，持续110天。在第60天测定血清促性腺激素和睾酮，并在第110天检查睾丸组织学。
结果
在对照糖尿病大鼠中，生精小管扩张，生精细胞排列不规则。精子发生停滞，精子细胞数量大幅减少，未观察到精子。在治疗组大鼠中，各类生精细胞基本正常。治疗组大鼠血清黄体生成素（LH）、卵泡刺激素（FSH）和睾酮水平高于对照组大鼠，但差异不显著。
结论
在实验性糖尿病大鼠中，女贞子提取物可保护实验性糖尿病对精子发生的损伤作用。
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