Buffington C A
Department of Veterinary Clinical Sciences, Ohio State University Veterinary Hospital, 601 Vernon L. Tharp Street, Columbus, OH 43210, USA.
Curr Pain Headache Rep. 2001 Feb;5(1):44-51. doi: 10.1007/s11916-001-0009-y.
Acute and persistent neuropathic and inflammatory injuries of healthy animals have contributed importantly to our current understanding of nociception and pain. Studies have differentiated somatic from visceral nociceptive input, and elucidated the pathways of transduction, transmission, perception, and modulation of the input. Other animal studies have identified important genetic and environmental influences on responses to nociception. Studies of naturally occurring visceral pain syndromes in animals also have added to our understanding of comparable syndromes in humans. Because of the aversive nature of pain, use of healthy animals to study pain in the service of other animals and humans is a decision to be taken carefully, and carries with it the responsibility of treating the animals as humanely as possible.
健康动物的急性和持续性神经性及炎症性损伤，对我们目前对伤害感受和疼痛的理解起到了重要作用。研究已经区分了躯体和内脏伤害性传入，并阐明了传入信号的转导、传递、感知和调制途径。其他动物研究已经确定了对伤害感受反应的重要遗传和环境影响。对动物自然发生的内脏疼痛综合征的研究也增进了我们对人类类似综合征的理解。由于疼痛具有厌恶性质，使用健康动物来研究疼痛以造福其他动物和人类是一个需要谨慎做出的决定，并且伴随着尽可能人道地对待动物的责任。
