HMR 3004、HMR 3647及红霉素对革兰氏阳性杆菌的杀菌活性及耐药性的产生

The bactericidal activities of HMR 3004, HMR 3647 and erythromycin against gram-positive bacilli and development of resistance.

作者信息

Fernández-Roblas R, Calvo R, Esteban J, Bryskier A, Soriano F

机构信息

Department of Medical Microbiology, Fundación Jiménez Díaz, Madrid, Spain.

出版信息

J Antimicrob Chemother. 1999 Feb;43(2):285-9. doi: 10.1093/jac/43.2.285.

DOI:10.1093/jac/43.2.285

PMID:11252337

Abstract

The bactericidal activities of two new ketolides, HMR 3004 and HMR 3647, and the potential to develop resistance to these two antibiotics were studied in Gram-positive bacilli. As judged by time-kill kinetics both ketolides were mostly bacteriostatic, being bactericidal against only highly susceptible isolates of Corynebacterium striatum (two isolates) and Corynebacterium minutissimum (one isolate). Spontaneous resistant mutants were detected in seven of 30 strains tested, mainly in Rhodococcus equi, C. minutissimum and C. striatum, with a very low frequency of mutation (10(-12)-10(-15)).

摘要

研究了两种新型酮内酯类药物HMR 3004和HMR 3647对革兰氏阳性杆菌的杀菌活性以及对这两种抗生素产生耐药性的可能性。根据时间杀菌动力学判断，两种酮内酯类药物大多具有抑菌作用，仅对纹带棒状杆菌（2株分离株）和极小棒状杆菌（1株分离株）的高度敏感分离株具有杀菌作用。在30株受试菌株中的7株中检测到自发耐药突变体，主要存在于马红球菌、极小棒状杆菌和纹带棒状杆菌中，突变频率非常低（10^(-12)-10^(-15)）。