SNARE介导的膜融合。

SNARE-mediated membrane fusion.

作者信息

Chen Y A, Scheller R H

机构信息

Renovis Inc., 747 Fifty Second Street, Oakland, California 94609, USA.

出版信息

Nat Rev Mol Cell Biol. 2001 Feb;2(2):98-106. doi: 10.1038/35052017.

DOI:10.1038/35052017

PMID:11252968

Abstract

SNARE proteins have been proposed to mediate all intracellular membrane fusion events. There are over 30 SNARE family members in mammalian cells and each is found in a distinct subcellular compartment. It is likely that SNAREs encode aspects of membrane transport specificity but the mechanism by which this specificity is achieved remains controversial. Functional studies have provided exciting insights into how SNARE proteins interact with each other to generate the driving force needed to fuse lipid bilayers.

摘要

有人提出SNARE蛋白介导所有细胞内膜融合事件。哺乳动物细胞中有30多个SNARE家族成员，每个成员都存在于不同的亚细胞区室中。SNAREs可能编码膜运输特异性的各个方面，但实现这种特异性的机制仍存在争议。功能研究为SNARE蛋白如何相互作用以产生融合脂双层所需的驱动力提供了令人兴奋的见解。