斑马鱼遗传学与脊椎动物心脏形成

Zebrafish genetics and vertebrate heart formation.

作者信息

Stainier D Y

机构信息

Department of Biochemistry and Biophysics, University of California, San Francisco, 513 Parnassus Avenue, Box 0448, San Francisco, California 94143-0448, USA.

出版信息

Nat Rev Genet. 2001 Jan;2(1):39-48. doi: 10.1038/35047564.

DOI:10.1038/35047564

PMID:11253067

Abstract

Forward-genetic analyses in Drosophila and Caenorhabditis elegans have given us unprecedented insights into many developmental mechanisms. To study the formation of organs that contain cell types and structures not present in invertebrates, a vertebrate model system amenable to forward genetics would be very useful. Recent work shows that a newly initiated genetic approach in zebrafish is already making significant contributions to understanding the development of the vertebrate heart, an organ that contains several vertebrate-specific features. These and other studies point to the utility of the zebrafish system for studying a wide range of vertebrate-specific processes.

摘要

对果蝇和秀丽隐杆线虫进行的正向遗传学分析，使我们对许多发育机制有了前所未有的深入了解。要研究包含无脊椎动物所没有的细胞类型和结构的器官的形成，一个适用于正向遗传学的脊椎动物模型系统将非常有用。最近的研究表明，斑马鱼中一种新启动的遗传方法，已经在理解脊椎动物心脏（一种具有多种脊椎动物特有的特征的器官）的发育方面做出了重大贡献。这些研究以及其他研究表明，斑马鱼系统在研究广泛的脊椎动物特有的过程方面具有实用性。