不断扩展的聚合酶世界。

The expanding polymerase universe.

作者信息

Goodman M F, Tippin B

机构信息

University of Southern California, Department of Biological Sciences and Chemistry, Stauffer Hall of Science 172, Los Angeles, California 90089-1340, USA.

出版信息

Nat Rev Mol Cell Biol. 2000 Nov;1(2):101-9. doi: 10.1038/35040051.

DOI:10.1038/35040051

PMID:11253362

Abstract

Over the past year, the number of known prokaryotic and eukaryotic DNA polymerases has exploded. Many of these newly discovered enzymes copy aberrant bases in the DNA template over which 'respectable' polymerases fear to tread. The next step is to unravel their functions, which are thought to range from error-prone copying of DNA lesions, somatic hypermutation and avoidance of skin cancer, to restarting stalled replication forks and repairing double-stranded DNA breaks.

摘要

在过去的一年里，已知的原核生物和真核生物DNA聚合酶的数量激增。这些新发现的酶中有许多能复制DNA模板中的异常碱基，而那些 “正统” 的聚合酶对此却望而却步。下一步是要弄清楚它们的功能，其功能被认为涵盖从容易出错地复制DNA损伤、体细胞超突变和避免皮肤癌，到重启停滞的复制叉以及修复双链DNA断裂等方面。