Keck P E, McElroy S L, Bennett J A
Biological Psychiatry Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA.
Bipolar Disord. 2000 Mar;2(1):42-6. doi: 10.1034/j.1399-5618.2000.020106.x.
The rapid and safe reduction of manic symptoms is an important initial goal of the pharmacologic treatment of acute mania. The pharmacokinetics and studies of pharmacologic loading of lithium, valproate, and carbamazepine were reviewed. In addition, the feasibility of administering other agents with potential efficacy in mania, e.g., atypical antipsychotics and new anticonvulsants, was discussed. Further double-blind, controlled studies with adequate sample sizes comparing loading strategies with more gradual titration schedules of candidate antimanic agents are needed.
快速且安全地减轻躁狂症状是急性躁狂症药物治疗的一个重要初始目标。本文综述了锂盐、丙戊酸盐和卡马西平的药代动力学及药物负荷研究。此外，还讨论了给予其他对躁狂症可能有效的药物（如非典型抗精神病药物和新型抗惊厥药）的可行性。还需要进一步开展样本量充足的双盲对照研究，以比较候选抗躁狂药物的负荷给药策略与更缓慢的滴定给药方案。
