[The concentration of adenylic nucleotides in vescular walls following application of octadine and ornid].

It was shown in experiments on rabbits that administration of octadine (10 mg/kg) and of ornid (10 mg/kg) and 1 hour (respectively) before the assessment failed to cause and changes in the adenylic nucleotides and inorganic phosphorus content in the aortic wall. Octadine administration led to reduction of the catecholamine level, but ornid, administered once or repeatedly, failed to cause any changes in the tissue catecholamine content. Repeated administration of these drugs in the same doses for 10 days caused an increase in the adenosinmonophosphoric acid content alone, without any essential changes in the other adenylic nucleotides and inorganic phosphorus content. An increase in the adenosinmonophosphoric acid content can be regarded as one of the mechanisms of pharmaco-mechanical relaxation of the smooth muscles in the vascular wall.