Bastin J, Sofack F, Boulekbache H, Bismuth J, Geloso J P
J Dev Physiol. 1986 Apr;8(2):97-103.
Adenine nucleotides have been measured in fetal and newborn kidneys of rat using the luciferine-luciferase method. In fetuses, between days 18 and 21 of gestation there is a drop of the relative amount of ATP in the renal nucleotide pool. Consequently, the kidneys of 21 days-old fetuses have lowered ATP/ADP ratio (3.6) and energy charge (0.80) compared with values found on day 18 (6.9 and 0.91, respectively); this relative energy deficit is heightened in progesterone induced postmaturity. One hour after delivery whether the gestational stage is 21, 22 or 23 days, there is a rise in ATP and a decrease in AMP content which restore a high energy level in kidney of the newborn and a 30% increase in the total adenine nucleotide pool.
采用荧光素-荧光素酶法测定了大鼠胎儿及新生鼠肾脏中的腺嘌呤核苷酸。在妊娠18至21天的胎儿中，肾脏核苷酸池中ATP的相对含量下降。因此，与妊娠18天时的值（分别为6.9和0.91）相比，21日龄胎儿的肾脏ATP/ADP比值（3.6）和能荷（0.80）降低；在孕酮诱导的过期产中，这种相对能量不足会加剧。无论妊娠阶段是21天、22天还是23天，出生后1小时，ATP含量会升高，AMP含量会降低，从而使新生鼠肾脏恢复高能量水平，腺嘌呤核苷酸总量增加30%。
