Jeng M R, Feusner J
Department of Pediatric Hematology/Oncology, Children's Hospital Oakland, Oakland, California, USA.
Pediatr Hematol Oncol. 2001 Mar;18(2):137-42. doi: 10.1080/088800101300002973.
A boy with acute lymphoblastic leukemia (ALL) experienced life-threatening vincristine neurotoxicity while simultaneously exposed to itraconazole. Five pediatric and six adult cases of itraconazole-enhanced vincristine toxicity have been reported, all with ALL. Upon cessation of the itraconazole, the patient's symptoms resolved, which is similar to the outcome of the previously reported cases: 10 of 11 patients had complete resolution of symptoms.
一名患有急性淋巴细胞白血病（ALL）的男孩在同时接触伊曲康唑时经历了危及生命的长春新碱神经毒性。已有5例儿科和6例成人病例报告了伊曲康唑增强长春新碱毒性的情况，所有病例均为ALL。停用伊曲康唑后，患者症状缓解，这与先前报告的病例结果相似：11例患者中有10例症状完全缓解。
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