Aguilar Rebolledo F
Unidad de Investigación en Epidemiología Clínica y Neurología CMN, Siglo XXI, IMSS.
Rev Invest Clin. 2000 Nov-Dec;52(6):665-79.
Interferon (INF) plays an important role in the immune response against viral infections. INF is part of the big cytokines family. It has also shown modulating activity on numerous components of the immune system; it inhibits cellular division, thus counteracting proliferation of cancerogenic cells. It has also the ability to reduce complications in multiple sclerosis by immunologic mechanism involving. Th2 responses. Recently, the utility of INF in neurological cases has been explored. Good results have been observed using recombinant INF beta-1a and glucosylated INF beta-1 in patients with active multiple sclerosis relapsing-remitting type (MS RR), in whom decreases the incidence and complications and possibly halts the progression of the disease. This manuscript will reviews the biologic activity of INF, the use, side effects and indications for using different INF's in neurological diseases specially in multiple sclerosis, particularly INF beta which are broadly accepted for clinical use in this pathology. We mention the Expanded Disability Status Scale (EDSS) to evaluate clinical involvement and recuperation after management.
干扰素（INF）在针对病毒感染的免疫反应中发挥着重要作用。干扰素是大细胞因子家族的一部分。它还对免疫系统的众多成分表现出调节活性；它抑制细胞分裂，从而对抗癌细胞的增殖。它还能够通过涉及Th2反应的免疫机制减少多发性硬化症的并发症。最近，已经探索了干扰素在神经疾病中的效用。在复发缓解型活动性多发性硬化症（MS RR）患者中使用重组干扰素β-1a和糖基化干扰素β-1已观察到良好效果，其中疾病的发病率和并发症降低，并且可能阻止疾病进展。本手稿将综述干扰素的生物学活性、在神经疾病特别是多发性硬化症中使用不同干扰素的用途、副作用和适应症，尤其是在该病理学中被广泛接受用于临床的干扰素β。我们提及扩展残疾状态量表（EDSS）以评估治疗后的临床受累情况和恢复情况。
