Tan P L, Jacobson R M, Poland G A, Jacobsen S J, Pankratz V S
Department of Paediatrics, National University Hospital, Singapore.
Vaccine. 2001 Mar 21;19(17-19):2434-9. doi: 10.1016/s0264-410x(00)00468-0.
Estimating the magnitude of the genetic contribution to the overall variation of antibody levels among individuals should help clarify the role of genetic association in the biological mechanism of vaccine response and failure. This, in turn, should help guide the design of improved vaccines with enhanced efficacy.
To explore the magnitude of genetic influence on antibody levels following measles, mumps and rubella vaccines.
Cross-sectional survey study.
Olmsted County, Minnesota.
Healthy twin-pairs. Of the 100 twin-pairs enrolled, 45 were monozygotic.
Determinations of zygosity, vaccine status, and quantitative IgG to measles, mumps, and rubella.
Heritability (ratio of genetic variance to total variance).
The number of vaccine-doses, the age at initial immunization, and the time between immunization and sampling did not differ between monozygotic and dizygotic twin pairs. The genetic variance - the variance in antibody levels presumably due to genetic effects - was 0.49 for measles, 0.54 for mumps, and 0.13 for rubella. Heritability, the ratio of genetic variance to total variance, was 88.5% for measles, with the lower bound of a one-sided 95% confidence interval equal to 52.4%. The heritability was, for mumps, 38.8% with a lower bound of 1.60%. The heritability for rubella was 45.7% with a lower bound of 4.94%.
Our data support the concept that genetic influences play a substantial role in the variation of antibody levels following immunization against measles and, to a lesser extent, mumps and rubella.
估计基因对个体间抗体水平总体变异的贡献程度，应有助于阐明基因关联在疫苗反应及失效生物学机制中的作用。反过来，这应有助于指导设计疗效更佳的改良疫苗。
探讨基因对麻疹、腮腺炎和风疹疫苗接种后抗体水平的影响程度。
横断面调查研究。
明尼苏达州奥尔姆斯特德县。
健康双胞胎对。在登记的100对双胞胎中，45对为同卵双胞胎。
确定合子性、疫苗接种状态以及针对麻疹、腮腺炎和风疹的定量IgG。
遗传力（基因方差与总方差之比）。
同卵和异卵双胞胎对之间，疫苗接种剂量、初次免疫年龄以及免疫与采样之间的时间并无差异。基因方差（推测因基因效应导致的抗体水平方差），麻疹为0.49，腮腺炎为0.54，风疹为0.13。遗传力，即基因方差与总方差之比，麻疹为88.5%，单侧95%置信区间下限为52.4%。腮腺炎的遗传力为38.8%，下限为1.60%。风疹的遗传力为45.7%，下限为4.94%。
我们的数据支持这样的观点，即基因影响在麻疹疫苗接种后抗体水平的变异中起重要作用，在腮腺炎和风疹疫苗接种后抗体水平变异中作用较小。
