Mazella J
Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, UPR 0411, Sophia Antipolis, 660 route des Lucioles, 06560, Valbonne, France.
Cell Signal. 2001 Jan;13(1):1-6. doi: 10.1016/s0898-6568(00)00130-3.
The identification of gp95sortilin, a sorting protein, as being the 100 kDa neurotensin (NT) receptor, a non-G-protein coupled receptor, constitutes a new and interesting but intriguing step in the neuropeptide signaling as well as in cellular trafficking. The isolation of the same protein by three different experimental approaches sum up the complexity for researchers involved in the functional significance of the so-called sortilin/neurotensin receptor 3 (NTR3). This review will concentrate on the putative physiological and cellular roles of sortilin/NTR3 as most results so far have proposed hypothetical conclusions rather than concrete evidence.
分选蛋白gp95sortilin被鉴定为100 kDa神经降压素（NT）受体，这是一种非G蛋白偶联受体，在神经肽信号传导以及细胞运输方面构成了一个新的、有趣但引人入胜的进展。通过三种不同实验方法分离出同一蛋白，这凸显了研究所谓的sortilin/神经降压素受体3（NTR3）功能意义的研究人员所面临的复杂性。由于目前大多数结果都只是提出了假设性结论而非确凿证据，因此本综述将聚焦于sortilin/NTR3假定的生理和细胞作用。
