己酮可可碱治疗对局限性硬皮病患者的白细胞介素-2（IL-2）和可溶性白细胞介素-2受体（sIL-2R）的血浆水平无影响。
Pentoxyfilline treatment does not influence the plasma levels of IL-2 and sIL-2R in limited scleroderma patients.
作者信息
Chibowska M, Krasowska D, Weglarz J
机构信息
Department of Dermatology, Medical University, ul. Radziwillowska 13, 20-250 Lublin, Poland.
出版信息
Med Sci Monit. 2001 Mar-Apr;7(2):282-8.
BACKGROUND
In this study we investigated whether plasma level of IL-2 or sIL-2R shows the clinical disease status.
MATERIAL AND METHODS
Plasma levels of IL-2 and sIL-2R were measured by ELISA in 23 patients with limited scleroderma (1SSc-acrosclerosis) and compared with 12 healthy women.
RESULTS
Plasma levels of sIL-2R in the group of patients with severe internal organs involvement (3446.1 +/- 1329.7 pg/ml) were significantly higher compared with those with minimal internal organs involvement (1606.4 +/- 507.3 pg/ml). Plasma level of IL-2 in the group of patients with severe internal organs involvement (8.12 +/- 7.77 pg/ml) did not differ much from that of the patients with minimal internal organs involvement (7.42 +/- 9.28 pg/ml). Treatment with pentoxyfilline did not influence the plasma levels of IL-2 and sIL-2R.
CONCLUSIONS
We concluded that elevated plasma levels of IL-2 and sIL-2R are markers of internal organ involvement in scleroderma.
背景
在本研究中，我们调查了白细胞介素-2（IL-2）或可溶性白细胞介素-2受体（sIL-2R）的血浆水平是否显示临床疾病状态。
材料与方法
采用酶联免疫吸附测定法（ELISA）测量了23例局限性硬皮病（1型系统性硬化症-肢端硬化型）患者的IL-2和sIL-2R血浆水平，并与12名健康女性进行比较。
结果
严重内脏受累患者组的sIL-2R血浆水平（3446.1±1329.7 pg/ml）显著高于轻度内脏受累患者组（1606.4±507.3 pg/ml）。严重内脏受累患者组的IL-2血浆水平（8.12±7.77 pg/ml）与轻度内脏受累患者组（7.42±9.28 pg/ml）差异不大。己酮可可碱治疗对IL-2和sIL-2R的血浆水平没有影响。
结论
我们得出结论，IL-2和sIL-2R血浆水平升高是硬皮病内脏受累的标志物。
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