García Ruiz P J, Cenjor C, Ulmer E, Hernández J, Cantarero S, Fanjul S, García de Yébenes J
Servicios de Neurología y Otorrinolaringología, Fundación Jiménez Díaz, Madrid.
Neurologia. 2001 Feb;16(2):70-3.
Oculomotor abnormalities, especially slow saccades, have long been recognized in Huntington's disease (HD).
To study prospectively horizontal saccade velocity by videonystagmography in 21 patients with genetically confirmed HD. The study included a baseline analysis and a second evaluation after 18.8 +/- 7.1 months. We included a control group of 15 subjects.
HD group exhibited decreased saccade velocity when compared with that from a control group (for predictive and unpredictive target). HD patients showed decreased saccade velocity with the passage of time (for predictive target, p < 0.01). Finally we found statistical significant correlation between saccade velocity and triplet length.
The measurement of saccade velocity might be an objective method to study the natural evolution of HD, and thus evaluate the effectiveness of future therapies.
动眼神经异常，尤其是慢扫视，长期以来在亨廷顿舞蹈症（HD）中已被确认。
通过视频眼震图前瞻性研究21例基因确诊的HD患者的水平扫视速度。该研究包括基线分析以及18.8±7.1个月后的第二次评估。我们纳入了15名受试者作为对照组。
与对照组相比，HD组的扫视速度降低（针对预测性和非预测性目标）。随着时间推移，HD患者的扫视速度降低（针对预测性目标，p<0.01）。最后，我们发现扫视速度与三联体长度之间存在统计学显著相关性。
测量扫视速度可能是研究HD自然病程的一种客观方法，从而评估未来治疗的有效性。
