Kiratli P O, Kiratli H, Bozkurt F, Ercan M T, Bilgiç S
Department of Nuclear Medicine, Hacettepe University Medical School, Ankara, Turkey.
Nucl Med Commun. 2001 Feb;22(2):197-201. doi: 10.1097/00006231-200102000-00012.
A prospective study with a new tumour-seeking agent, 99Tcm-glutathione (GSH), was performed on 17 patients with choroidal melanoma. Planar and SPECT images using 99Tcm-GSH clearly demonstrated melanotic melanoma but failed to show amelonotic melanomas. Following confirmation of our results by concurrent ultrasonography and magnetic resonance imaging or computed tomography, patients were managed by either 125I plaque brachytherapy, diode laser transpupillary thermotherapy or enucleation depending on the site and location. In combination with other diagnostic tests, 99Tcm-GSH scintigraphy may play a role in the detection of uveal melanoma and its possible distant metastases.
一项针对17例脉络膜黑色素瘤患者，使用新型肿瘤寻踪剂99锝-谷胱甘肽（GSH）进行的前瞻性研究。利用99锝-GSH进行的平面和单光子发射计算机断层扫描（SPECT）图像清晰显示了黑色素性黑色素瘤，但未能显示无黑色素性黑色素瘤。在通过同步超声检查、磁共振成像或计算机断层扫描确认我们的结果后，根据肿瘤的部位和位置，患者接受了125碘敷贴近距离放射治疗、二极管激光经瞳孔温热疗法或眼球摘除术。与其他诊断测试相结合，99锝-GSH闪烁扫描术可能在葡萄膜黑色素瘤及其可能的远处转移灶的检测中发挥作用。
