Dickson D H
Can J Ophthalmol. 1975 Apr;10(2):227-38.
The morphology of the anterior border of the primate iris has been examined by transmission and scanning electron microscopy. The results confirm that the anterior iris is composed of heavily pigmented melanocytes, fibroblasts, and a loosely arranged network of collagen fibres. The melanocytes are slender, elongate structures, which show some branching in the peripheral iris. They run parallel to the surface and are filled with spindle-shaped pigment granules which are oriented in the long axis of the cell. In the miotic state, the peripheral iris melanocytes form a dense, interlacing network. As the pupillary margin is approached, the angles between intersecting melanocytes diminish; the melanocytes appear to be parallel and in close contact with one another.During mydriasis, the peripheral iris melanocytes are compressed and pupillary components are found to intersect at angles greater than 90%. The superficial fibroblasts are flattened cells, closely applied to the underlying melanocyte processes and in the mydriatic iris form a resonably continous monolayer over the anterior iris surface. Iris pores are present, exposing the underlying melanocytes and stromal collagen. During miosis, the surface fibroblasts become attenuated and the pores increase in size and number. This paper demonstrates the value of the scanning electron microscope in presenting an accurate three dimensional model of the iris.
通过透射电子显微镜和扫描电子显微镜对灵长类动物虹膜前缘的形态进行了研究。结果证实，虹膜前部由色素沉着严重的黑素细胞、成纤维细胞和排列疏松的胶原纤维网络组成。黑素细胞是细长的结构，在虹膜周边有一些分支。它们与表面平行，充满了沿细胞长轴排列的纺锤形色素颗粒。在瞳孔缩小状态下，周边虹膜黑素细胞形成致密的交错网络。随着接近瞳孔边缘，相交黑素细胞之间的角度减小；黑素细胞似乎相互平行且紧密接触。在瞳孔散大期间，周边虹膜黑素细胞受到挤压，发现瞳孔成分以大于90%的角度相交。表面成纤维细胞是扁平细胞，紧密贴附于下方的黑素细胞突起，在瞳孔散大的虹膜中，在前部虹膜表面形成相当连续的单层。虹膜存在孔隙，使下方的黑素细胞和基质胶原暴露出来。在瞳孔缩小时，表面成纤维细胞变薄，孔隙大小和数量增加。本文展示了扫描电子显微镜在呈现准确的虹膜三维模型方面的价值。
