Mehr I J
Pharmacogenomic Services, Laboratory Corporation of America, Research Triangle Park, NC 27709, USA.
Pharmacogenomics. 2000 Feb;1(1):1-4. doi: 10.1517/14622416.1.1.1.
Pharmacogenomics seeks to apply the field of genomics to improve the efficacy and safety of therapeutics. Sinmply put, pharmacogenomics is genetic-based testing to determine patient therapy. Interestingly, the clinical lab has rarely been discussed within the context of pharmacogenomics. Since clinical labs fill a key role in drug development it is important that they are included in pharmacogenomic discussions. Currently, clinical labs assist pharmaceutical sponsors in preclinical pharmacogenetic testing. In the future, clinical labs will be looked to for genetic test development and validation, and high-throughput genotyping of patients in clinical trials and routine testing. Clinical labs are an essential link in the chain of pharmacogenomic drug development, a fact which must be recognised by both the labs themselves and the industry as a whole.
药物基因组学旨在应用基因组学领域的知识来提高治疗药物的疗效和安全性。简而言之，药物基因组学是基于基因的检测，用于确定患者的治疗方案。有趣的是，临床实验室在药物基因组学的背景下很少被讨论。由于临床实验室在药物开发中起着关键作用，将它们纳入药物基因组学的讨论中很重要。目前，临床实验室协助制药赞助商进行临床前药物遗传学检测。未来，临床实验室将负责基因检测的开发和验证，以及对临床试验和常规检测中的患者进行高通量基因分型。临床实验室是药物基因组学药物开发链条中的重要环节，这一事实必须得到实验室自身以及整个行业的认可。
