Cuthbert A W
Department of Medicine, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
Biol Chem. 2001 Jan;382(1):57-60. doi: 10.1515/BC.2001.009.
Kinin effects on epithelial electrogenic ion transport are reviewed, with reference to the alimentary tract. The transported ion is usually chloride, but some epithelia also transport bicarbonate. The key components of the transport system are the sodium-potassium-chloride cotransporter, Na+-K+ ATPase (both located basolaterally) and the CFTR chloride channel (located apically). Activation of K+-channels in both membranes may secondarily affect the anion transport mechanism. The types of kinin receptors that cause chloride secretion, the second messengers involved and the possible functional responsibilities of the kinin-activated secretory mechanism are discussed.
本文参考消化道综述了激肽对上皮细胞电生性离子转运的影响。所转运的离子通常为氯离子，但某些上皮细胞也转运碳酸氢根离子。转运系统的关键组成部分是钠-钾-氯共转运体、钠钾ATP酶（均位于基底外侧）和囊性纤维化跨膜传导调节因子氯离子通道（位于顶端）。两膜中钾离子通道的激活可能继而影响阴离子转运机制。本文讨论了引起氯离子分泌的激肽受体类型、所涉及的第二信使以及激肽激活的分泌机制可能的功能作用。
