Sorbie J, Valberg L S, Corbett W E, Ludwig J
Can Med Assoc J. 1975 May 17;112(10):1173-8.
Serum ferritin concentration was measured by immunoradiometric assay in 64 subjects. It was closely related to the size of body iron stores measured by hemosiderin content of bone marrow in all subjects and by the deferoxamine test in 10 patients with iron overload. Urinary cobalt excretion, an indirect measure of iron absorption, was inversely related to hemosiderin content of bone marrow in 34 patients aged 18 to 72 with or without liver disease, but this relation did not hold in a group of 20 student volunteers aged 17 to 30, indicating that the test is unreliable in young people. A strong inverse correlation was demonstrated between values for cobalt excretion and serum ferritin in the 34 patients and between those for iron absorption and serum ferritin in the 20 students. Serum ferritin concentration appears to reflect accurately the iron status of the healthy individual but high values in liver disease must be interpreted with caution.
采用免疫放射分析法对64名受试者的血清铁蛋白浓度进行了测定。在所有受试者中，血清铁蛋白浓度与通过骨髓含铁血黄素含量测定的体内铁储存量密切相关；在10例铁过载患者中，血清铁蛋白浓度与通过去铁胺试验测定的体内铁储存量密切相关。尿钴排泄是铁吸收的一项间接指标，在34例年龄在18至72岁、患有或未患有肝病的患者中，尿钴排泄与骨髓含铁血黄素含量呈负相关，但在20名年龄在17至30岁的学生志愿者中，这种关系并不成立，这表明该检测方法在年轻人中不可靠。在34例患者中，钴排泄值与血清铁蛋白之间以及在20名学生中，铁吸收与血清铁蛋白之间均呈现出强烈的负相关。血清铁蛋白浓度似乎能准确反映健康个体的铁状态，但对于肝病患者血清铁蛋白浓度升高的情况，必须谨慎解读。
