Hartmann N R, Gilbert C W, Jansson B, MacDonald P D, Steel G G, Valleron A J
Cell Tissue Kinet. 1975 Mar;8(2):119-24. doi: 10.1111/j.1365-2184.1975.tb01213.x.
Computer methods developed by the authors for analysis of fraction labelled mitoses curves (FLM curves) have been compared. Four test examples were used in the study; the first example was the synthesis of a FLM curve with fixed parameters and the others involved fitting actual data. Experimental FLM curves showing various degrees of damping were used in the curve fitting tests. In each test example the comparison was based on the assumptions of exponential growth, a growth fraction of unity and no cell loss. In three of the test examples good agreement between the methods was observed but in one example some important discrepancies arose in the analysis of a heavily damped FLM curve.
作者开发的用于分析标记有丝分裂分数曲线（FLM曲线）的计算机方法已被比较。该研究使用了四个测试示例；第一个示例是具有固定参数的FLM曲线的合成，其他示例涉及对实际数据进行拟合。曲线拟合测试中使用了显示不同程度阻尼的实验性FLM曲线。在每个测试示例中，比较是基于指数增长、生长分数为1且无细胞损失的假设。在三个测试示例中，观察到方法之间有很好的一致性，但在一个示例中，对严重阻尼的FLM曲线进行分析时出现了一些重要差异。
