Cidis Meltzer C, Drevets W C, Price J C, Mathis C A, Lopresti B, Greer P J, Villemagne V L, Holt D, Mason N S, Houck P R, Reynolds C F, DeKosky S T
Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15231, USA.
Brain Res. 2001 Mar 23;895(1-2):9-17. doi: 10.1016/s0006-8993(00)03211-x.
The effects of age on serotonergic function have been hypothesized to underlie age-related changes in mood and behaviors such as sleep and eating. Of particular interest is the serotonin type-1A (5-HT1A) receptor, due to its putative role in mediating the therapeutic efficacy of antidepressant treatment. Using positron emission tomography (PET) and [11C--carbonyl] WAY100635, we assessed 5-HT1A receptor binding in 21 healthy subjects (10 men, 11 women) ranging in age from 21 to 80 years. Regional binding potential values were generated using a reference tissue model and corrected for partial volume effects. We observed an inverse relationship between age and binding of [11C--carbonyl] WAY100635 to the 5-HT1A receptor in men, but not women. This finding is in accord with observations reported in the postmortem literature. Gender-specific effects of age on central serotonergic function may relate to differences between men and women in behavior, mood, and susceptibility to neuropsychiatric disease across the adult lifespan.
年龄对血清素能功能的影响被认为是情绪和行为（如睡眠和饮食）中与年龄相关变化的基础。血清素1A（5-HT1A）受体尤其受到关注，因为它在介导抗抑郁治疗的疗效中可能发挥作用。我们使用正电子发射断层扫描（PET）和[11C-羰基] WAY100635，评估了21名年龄在21至80岁之间的健康受试者（10名男性，11名女性）的5-HT1A受体结合情况。使用参考组织模型生成区域结合潜能值，并对部分容积效应进行校正。我们观察到男性中年龄与[11C-羰基] WAY100635与5-HT1A受体的结合呈负相关，而女性中则没有。这一发现与死后文献中报道的观察结果一致。年龄对中枢血清素能功能的性别特异性影响可能与成年期男女在行为、情绪和神经精神疾病易感性方面的差异有关。
