通过[11C]WAY-100635和正电子发射断层扫描（PET）测量发现，血清素5-HT1A受体结合潜能随年龄增长而下降。

Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET.

作者信息

Tauscher J, Verhoeff N P, Christensen B K, Hussey D, Meyer J H, Kecojevic A, Javanmard M, Kasper S, Kapur S

机构信息

PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.

出版信息

Neuropsychopharmacology. 2001 May;24(5):522-30. doi: 10.1016/S0893-133X(00)00227-X.

DOI:10.1016/S0893-133X(00)00227-X

PMID:11282252

Abstract

Positron emission tomography (PET) and [11C]WAY-100635 were used to examine the effect of age on serotonin-1A (5-HT1A) receptor binding potential (BP) in 19 healthy subjects. Regions of interest (ROI) were drawn on the co-registered magnetic resonance imaging (MRI) in orbitofrontal (OFC), dorsolateral prefrontal (DLPFC), anterior cingulate (ACC), lateral (LTC), and mediotemporal (MTC), parietal, occipital and cerebellar cortex, and the raphe nuclei. BP values were calculated using a simplified reference tissue method. In addition, a voxelwise analysis was performed using SPM99. Voxelwise analysis revealed a significant global decrease of 5-HT(1A) BP with age (set level <.001). ROI analysis revealed significant age-related 5-HT(1A) BP decreases in DLPFC (r = -0.56), ACC (r = -0.44), OFC (r = -0.42), LTC (r = -0.40), parietal (r = -0.65), and occipital cortex (r = -0.43), but not in MTC or raphe nuclei. Overall, cortical 5-HT(1A) BP declined by approximately 10% per decade, except for the MTC, where we did not find a significant age effect. Hence, careful age matching may be recommended for future studies using PET and [11C]WAY-100635 to examine 5-HT1A receptors.

摘要

采用正电子发射断层扫描（PET）和[11C]WAY-100635对19名健康受试者进行研究，以检测年龄对血清素-1A（5-HT1A）受体结合潜能（BP）的影响。在眶额皮质（OFC）、背外侧前额叶皮质（DLPFC）、前扣带回（ACC）、外侧颞叶皮质（LTC）、内侧颞叶皮质（MTC）、顶叶、枕叶和小脑皮质以及中缝核的共同配准磁共振成像（MRI）上绘制感兴趣区域（ROI）。使用简化参考组织法计算BP值。此外，使用SPM99进行体素分析。体素分析显示，5-HT(1A) BP随年龄显著整体下降（设定水平<.001）。ROI分析显示，DLPFC（r = -0.56）、ACC（r = -0.44）、OFC（r = -0.42）、LTC（r = -0.40）、顶叶（r = -0.65）和枕叶皮质（r = -0.43）中5-HT(1A) BP随年龄显著下降，但MTC或中缝核中未出现这种情况。总体而言，除MTC外，皮质5-HT(1A) BP每十年下降约10%，在MTC中我们未发现显著的年龄效应。因此，对于未来使用PET和[11C]WAY-100635检测5-HT1A受体的研究，建议仔细进行年龄匹配。