Yamaya M, Hosoda M, Ishizuka S, Monma M, Matsui T, Suzuki T, Sekizawa K, Sasaki H
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.
Clin Exp Allergy. 2001 Mar;31(3):417-22. doi: 10.1046/j.1365-2222.2001.01013.x.
Carbon monoxide (CO) can be detected in exhaled air and is increased in asthmatic patients not treated with corticosteroids. However, it is uncertain whether exhaled CO is related to severity of asthma. To study whether exhaled CO is related to severity of asthma in clinical courses, exhaled CO concentrations were measured on a CO monitor by vital capacity manoeuvre in 20 mild asthmatics treated with inhaled beta2-agonists alone, 20 moderate asthmatics treated with inhaled corticosteroids, and 15 stable asthmatics treated with high dose inhaled corticosteroids and oral corticosteroids once a month over 1 years. Exhaled CO concentrations were also measured in 16 unstable severe asthmatics who visited the hospital every 7 or 14 days for treatment with high dose inhaled corticosteroids and oral corticosteroids. The mean values of exhaled CO in severe asthma over 1 year were 6.7 +/- 9.5 p.p.m. (n = 31, mean +/- SD) and significantly higher than those of non-smoking control subjects (1.2 +/- 0.9 p.p.m., n = 20, P < 0.01). Exhaled CO concentrations in unstable severe asthmatics were significantly higher than those in stable severe asthmatics. However, exhaled CO concentrations in mild and moderate asthmatics did not differ significantly from those in non-smoking control subjects (P > 0.20). There was a significant relationship between the exhaled CO concentrations and forced expiratory volume in one second in all asthmatic patients. These findings suggest that exhaled CO concentrations may relate to the severity of asthma and measurements of exhaled CO concentrations may be a useful means of monitoring airway inflammation in asthma.
呼出气体中可检测到一氧化碳（CO），且未接受皮质类固醇治疗的哮喘患者呼出气体中的一氧化碳含量会升高。然而，呼出的CO是否与哮喘严重程度相关尚不确定。为了研究在临床病程中呼出的CO是否与哮喘严重程度相关，我们通过肺活量动作，使用CO监测仪测量了20名单独吸入β2激动剂治疗的轻度哮喘患者、20名吸入皮质类固醇治疗的中度哮喘患者以及15名每月接受一次高剂量吸入皮质类固醇和口服皮质类固醇治疗达1年的稳定哮喘患者呼出的CO浓度。我们还测量了16名不稳定重度哮喘患者呼出的CO浓度，这些患者每7或14天到医院接受高剂量吸入皮质类固醇和口服皮质类固醇治疗。重度哮喘患者1年中呼出CO的平均值为6.7±9.5 ppm（n = 31，平均值±标准差），显著高于非吸烟对照受试者（1.2±0.9 ppm，n = 20，P < 0.01）。不稳定重度哮喘患者呼出的CO浓度显著高于稳定重度哮喘患者。然而，轻度和中度哮喘患者呼出的CO浓度与非吸烟对照受试者相比无显著差异（P > 0.20）。在所有哮喘患者中，呼出的CO浓度与一秒用力呼气量之间存在显著相关性。这些发现表明，呼出的CO浓度可能与哮喘严重程度相关，测量呼出的CO浓度可能是监测哮喘气道炎症的一种有用方法。
