Kirby B, Marsland A M, Carmichael A J, Griffiths C E
Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester, UK.
Clin Exp Dermatol. 2001 Jan;26(1):27-9. doi: 10.1046/j.1365-2230.2001.00753.x.
Plaques of psoriasis contain increased levels of cytokines, including tumour necrosis factor-alpha (TNF-alpha), which are thought to be essential to the maintenance of the psoriatic process. We report the successful treatment of severe, recalcitrant psoriasis when infliximab (a monoclonal antibody to TNF-alpha) was used in combination with methotrexate.
