热稳定碱性磷酸酶对左旋咪唑（R12456）的耐药性。
Resistance to Levamisole (R12456) in heat-stable alkaline phosphatases.
作者信息
Chan A W, Kellen J A
出版信息
Clin Chim Acta. 1975 Apr 2;60(1):91-6. doi: 10.1016/0009-8981(75)90184-9.
PMID:1126034
Abstract
The inhibitory effect of Levamisole (R12456) on human alkaline phosphatases has been studied. At a concentration of 0.1 mM it is possible to differentiate the source of the enzyme. Enzyme activity relatively resistant to Levamisole (less than 20 percent loss) is present in serum with the Regan isoenzyme, in placental extracts, in the intestinal "B" preparation and in heat-stable alkaline phosphatases "unmasked" after treatment at high ionic strength.
摘要
已对左旋咪唑（R12456）对人碱性磷酸酶的抑制作用进行了研究。在浓度为0.1 mM时，可以区分该酶的来源。血清中的里根本同工酶、胎盘提取物、肠道“B”制剂以及在高离子强度处理后“暴露”的热稳定碱性磷酸酶中存在对左旋咪唑相对抗性的酶活性（损失小于20%）。
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