Bisschop D Y, Alardo J P, Razgallah B, Just B Y, Germain M L, Millart H G, Trenque T C
Centre Régional de Pharmacovigilance, Hôpital Maison Blanche, Reims, France.
Ann Pharmacother. 2001 Mar;35(3):311-3. doi: 10.1345/aph.10200.
To report development of a seizure after administration of ropivacaine.
A 26-year-old woman was scheduled for a cesarean section because of a stagnation of the uterine neck dilatation after 4.5 hours. After peridural administration of 279 mg of ropivacaine (total dose) over five hours, she presented with oculogyric movements and slurred speech that preceded convulsions of the face and of the upper limbs.
Convulsions are well-known complications of local anesthetics. Ropivacaine, a relatively new agent, is considered safer for the central nervous system. Currently, there are only four published reports that implicate ropivacaine as being associated with convulsions. The likelihood that ropivacaine caused the seizure in our patient was possible based on the Naranjo probability scale.
Clinicians should be aware of the possibility of seizures as an adverse effect of ropivacaine.
报告罗哌卡因给药后发生癫痫发作的情况。
一名26岁女性因宫颈扩张停滞4.5小时后计划行剖宫产术。在五小时内硬膜外给予279毫克罗哌卡因（总剂量）后，她出现眼球向上凝视运动和言语含糊，随后面部和上肢抽搐。
惊厥是局部麻醉药的常见并发症。罗哌卡因是一种相对较新的药物，被认为对中枢神经系统更安全。目前，仅有四篇已发表的报告表明罗哌卡因与惊厥有关。根据纳伦霍概率量表，罗哌卡因导致我们患者癫痫发作的可能性是存在的。
临床医生应意识到癫痫发作作为罗哌卡因不良反应的可能性。
