Brake J, Cummings T S, Pinedo C R, Bafundo K W
Department of Poultry Science, College of Agriculture and Life Sciences, North Carolina State University, Raleigh 27695-7608, USA.
Poult Sci. 2001 Mar;80(3):260-5. doi: 10.1093/ps/80.3.260.
Three experiments were conducted to assess the effects on broiler breeders of contamination of feed with the ionophore anticoccidial semduramicin. In Experiment 1, individually caged females received 0, 12.5, or 25 mg/kg diet for 3 wk from 48 to 50 wk of age. In Experiment 2, males and females in floor pens received 0, 12.5, or 25 mg/kg diet for 3 wk from 63 to 65 wk of age. In Experiment 3, individually caged males and females received 0, 3, 6, or 25 mg/kg diet for 1 wk at 31 wk of age and were mated by artificial insemination. There was a dose-related decrease in cumulative egg production and percentage shell in Experiment 1 after more than 1 wk exposure, but these effects were not observed in the other experiments. There was a decrease in cumulative fertile hatchability and a dose-related decrease after 3 wk exposure due to an increase in early embryonic mortality in Experiment 2, but these changes were not observed during the 1-wk exposure in Experiment 3. The data show that adverse effects of semduramicin require greater than 1 wk of exposure to be evident.
进行了三项试验，以评估离子载体抗球虫药赛杜霉素污染饲料对肉种鸡的影响。在试验1中，个体单笼饲养的母鸡在48至50周龄时，以0、12.5或25毫克/千克的剂量摄入饲料，持续3周。在试验2中，地面平养的公鸡和母鸡在63至65周龄时，以0、12.5或25毫克/千克的剂量摄入饲料，持续3周。在试验3中，个体单笼饲养的公鸡和母鸡在31周龄时，以0、3、6或25毫克/千克的剂量摄入饲料1周，然后进行人工授精。在试验1中，暴露超过1周后，累计产蛋量和蛋壳百分比呈剂量相关下降，但在其他试验中未观察到这些影响。在试验2中，暴露3周后，由于早期胚胎死亡率增加，累计受精孵化率下降且呈剂量相关，但在试验3的1周暴露期间未观察到这些变化。数据表明，赛杜霉素的不良影响需要暴露超过1周才会显现。
