Bohning D E, He L, George M S, Epstein C M
Department of Radiology, Medical University of South Carolina, Charleston 29425, USA.
J Neural Transm (Vienna). 2001;108(1):35-52. doi: 10.1007/s007020170095.
Transcranial magnetic stimulation (TMS) is a noninvasive method for local stimulation of cerebral cortex using a small coil's pulsed magnetic field. TMS response maps consist of measured responses to stimulations at points on a scalp-referenced grid and are used to study the topography of the brain's inhibitory and excitatory response. Because the magnetic field distributions of stimulation coils are 1-2 centimeters wide and 2-3 centimeters long, and the induced electric fields are even broader, the resolution of TMS maps is limited and the actual region of cortical stimulation is poorly defined. To better characterize the activation pattern, a practical mathematical procedure was developed for deconvolving a spherical model approximation of the coil's induced electric field distribution (here measured in a phantom) from the TMS response maps. This procedure offers an integrated, internally consistent method for processing TMS response maps to estimate the spatial distribution of motor cortex activations and inhibitions.
经颅磁刺激（TMS）是一种使用小线圈的脉冲磁场对大脑皮层进行局部刺激的非侵入性方法。TMS反应图谱由在头皮参考网格上各点对刺激的测量反应组成，用于研究大脑抑制性和兴奋性反应的地形图。由于刺激线圈的磁场分布宽1 - 2厘米、长2 - 3厘米，且感应电场更宽，TMS图谱的分辨率有限，皮层刺激的实际区域界定不清。为了更好地表征激活模式，开发了一种实用的数学程序，用于从TMS反应图谱中反卷积线圈感应电场分布的球形模型近似值（此处是在体模中测量的）。该程序提供了一种综合的、内部一致的方法来处理TMS反应图谱，以估计运动皮层激活和抑制的空间分布。
