Cane P A
Division of Immunity and Infection, University of Birmingham Medical School, Birmingham B15 2TT, UK.
Rev Med Virol. 2001 Mar-Apr;11(2):103-16. doi: 10.1002/rmv.305.
Human respiratory syncytial virus (RSV) is the major cause of lower respiratory tract disease in infants. It is unusual in that it causes repeated infections throughout life. Despite considerable efforts there is as yet no satisfactory vaccine available. This paper reviews the molecular epidemiology of the RSV and describes the complex genotypic structure of RSV epidemics. The evolution of the virus is discussed, with particular reference to the antigenic and genetic variability of the attachment glycoprotein.
人呼吸道合胞病毒（RSV）是婴儿下呼吸道疾病的主要病因。其不同寻常之处在于它会在一生中引发反复感染。尽管付出了巨大努力，但目前仍没有令人满意的疫苗。本文综述了RSV的分子流行病学，并描述了RSV流行的复杂基因型结构。文中讨论了该病毒的进化，特别提及了附着糖蛋白的抗原性和基因变异性。
