Aksoy M C, Tokgozoglu A M
Guvenlik Cad Ciftevler Sok No: 12-7 06540 A.Ayranci, Ankara, Turkey.
Arch Orthop Trauma Surg. 2001;121(3):162-5. doi: 10.1007/s004020000197.
Forty patients who were scheduled for a total hip arthroplasty were enrolled in a prospective study and were randomly divided into two groups. Group 1 received recombinant human erythropoietin (300 U/kg twice a week), and group 2 received placebo. The medication was started 2 weeks before the operation, and only one dose of medication was given after the operation. Autologous blood was administered at the same time as the medication until the hemoglobin level sank to 10 g/dl. Forty-eight and 49 units of autologous blood were collected in group 1 and group 2, respectively. Intraoperative homologous blood was transfused only to patients in group 2. Seven and 13 units of allogenic blood were transfused into group 1 and group 2 patients during the postoperative period, respectively. There were no any significant differences between the groups in terms of early postoperative hemoglobin level and amount of autologous blood collected. However, the increase of the reticulocyte count in patients who received erythropoietin was significantly higher than in the group 2 patients. The study showed that short-term and low-dose erythropoietin usage strongly stimulates the bone marrow. Erythropoietin administration and preoperative autologous blood donation diminished the total units of allogenic blood required during the intraoperative or postoperative period. Autologous blood administration without concurrent erythropoietin did not stimulate the bone marrow adequately.
40例计划行全髋关节置换术的患者被纳入一项前瞻性研究，并被随机分为两组。第1组接受重组人促红细胞生成素（每周两次，每次300 U/kg），第2组接受安慰剂。药物在手术前2周开始使用，术后仅给予一剂药物。在用药的同时采集自体血，直至血红蛋白水平降至10 g/dl。第1组和第2组分别采集了48单位和49单位的自体血。术中仅向第2组患者输注异体血。术后第1组和第2组患者分别输注了7单位和13单位的异体血。两组在术后早期血红蛋白水平和采集的自体血量方面无显著差异。然而，接受促红细胞生成素治疗的患者网织红细胞计数的升高明显高于第2组患者。该研究表明，短期、低剂量使用促红细胞生成素能强烈刺激骨髓。使用促红细胞生成素并术前进行自体血捐献减少了术中或术后所需异体血的总量。未同时使用促红细胞生成素的自体血采集未能充分刺激骨髓。
