Orkin S H
Division of Hematology, Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
Nat Rev Genet. 2000 Oct;1(1):57-64. doi: 10.1038/35049577.
Diverse types of blood cell (lineages) are produced from rare haematopoietic stem cells that reside in the bone marrow. This process, known as haematopoiesis, provides a valuable model for examining how genetic programs are established and executed in vertebrates, and also how homeostasis of blood formation is altered in leukaemias. So, how does an apparently small group of critical lineage-restricted nuclear regulatory factors specify the diversity of haematopoietic cells? Recent findings not only indicate how this may be achieved but also show the extraordinary plasticity of tissue stem cells in vivo.
多种类型的血细胞（谱系）由存在于骨髓中的罕见造血干细胞产生。这一过程，即造血作用，为研究脊椎动物中基因程序如何建立和执行，以及白血病中血液形成的稳态如何改变提供了一个有价值的模型。那么，一小群明显关键的谱系限制性核调节因子是如何确定造血细胞的多样性的呢？最近的研究结果不仅表明了这一点是如何实现的，还展示了体内组织干细胞非凡的可塑性。
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