The State Key Laboratory for Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, China.
The Institute of Blood Transfusion, Chinese Academy of Medical Sciences / Peking Union Medical College, Chengdu, China.
Adv Exp Med Biol. 2023;1442:159-175. doi: 10.1007/978-981-99-7471-9_10.
The hematopoietic stem cells (HSCs) have the ability to differentiate and give rise to all mature blood cells. Commitment to differentiation progressively limits the self-renewal potential of the original HSCs by regulating the level of lineage-specific gene expression. In this review, we will summarize the current understanding of the molecular mechanisms underlying HSC differentiation toward erythroid, myeloid, and lymphocyte lineages. Moreover, we will decipher how the single-cell technologies advance the lineage-biased HSC subpopulations and their differentiation potential.
造血干细胞（HSCs）具有分化为所有成熟血细胞的能力。通过调节谱系特异性基因表达水平，向特定谱系的分化逐渐限制原始 HSCs 的自我更新潜能。在这篇综述中，我们将总结 HSC 向红系、髓系和淋巴细胞谱系分化的分子机制的现有认识。此外，我们还将阐明单细胞技术如何推进谱系偏向性 HSC 亚群及其分化潜能。
