[HBsAg阳性孕妇血清乙肝病毒DNA载量与新生儿宫内感染的关系]
[The relationship of serum hepatitis B virus DNA load in HBsAg positive pregnant women to the intrauterine infection of newborns].
作者信息
Liu Z, Xu D, Yan Y
机构信息
Fourth Military Medical University, Xi' an 710033.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 1999 Mar;34(3):133-4.
OBJECTIVE
To study the relationship of serum hepatitis B virus (HBV) DNA load in HBsAg positive pregnant women to intrauterine infection of their newborns.
METHODS
Serum HBV DNA were determined by dot-blot hybridization in 185 HBsAg positive pregnant women. Serum HBsAg were tested by ELISA in their newborns within 24 hours after birth.
RESULTS
The prevalence of intrauterine HBV infection of the newborns was associated with the HBV DNA level of the mothers. With the increase of serum HBV DNA load, the risk of fetal intrauterine infection was increasing.
CONCLUSION
Fetal exposure to high level of maternal HBV DNA is one of the important determinant of intrauterine infection.
目的
研究HBsAg阳性孕妇血清乙肝病毒（HBV）DNA载量与其新生儿宫内感染的关系。
方法
采用斑点杂交法检测185例HBsAg阳性孕妇的血清HBV DNA。采用ELISA法检测其新生儿出生后24小时内的血清HBsAg。
结果
新生儿宫内HBV感染的发生率与母亲的HBV DNA水平有关。随着血清HBV DNA载量的增加，胎儿宫内感染的风险也在增加。
结论
胎儿暴露于高水平的母体HBV DNA是宫内感染的重要决定因素之一。
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