锂的施用可拮抗啮齿动物的胆碱能行为效应。
Lithium administration antagonizes cholinergic behavioral effects in rodents.
作者信息
Janowsky D S, Abrams A A, Groom G P, Judd L L, Cloptin P
出版信息
Psychopharmacology (Berl). 1979 May 25;63(2):147-50. doi: 10.1007/BF00429693.
PMID:112633
Abstract
Physostigmine, a centrally acting cholinesterase inhibitor, antagonizes methylphenidate-induced stereotyped gnawing behavior in mice and rats. This effect is significantly attenuated when lithium chloride is concurrently administered, indicating that lithium chloride may antagonize central cholinergic activity. This observation may have theoretical implications for an adrenergic-cholinergic balance hypothesis of affective disorders.
摘要
毒扁豆碱是一种中枢性胆碱酯酶抑制剂，可拮抗哌醋甲酯在小鼠和大鼠中引起的刻板啃咬行为。当同时给予氯化锂时，这种作用会显著减弱，这表明氯化锂可能拮抗中枢胆碱能活性。这一观察结果可能对情感障碍的肾上腺素能-胆碱能平衡假说具有理论意义。
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