Parageorgiou C, Dardoufas C, Kouloulias V, Ventouras E, Uzunoglu N, Vlahos L, Rambavilas A, Christodoulou G
Psychophysiology Laboratory, Psychiatry Clinic, Aiginiteion Hospital, Medical School, Athens, Greece.
J Neurooncol. 2000 Dec;50(3):275-85. doi: 10.1023/a:1006447624574.
The aim of this study was to show, whether a certain prophylacting applicable radiation affects the cognition, particularly, the specific cognitive components P50, N100, P300 and N400 of auditory event related potentials (ERPs) during a short memory test.
Eleven patients with small cell lung cancer (SCLC), who had presented complete response of disease after chemotherapy and radical radiotherapy in the lung, were prescribed to receive a prophylacting cranial irradiation (PCI) with a 6 MeV linear accelerator. The dose schedule was consisting of a total dose up to 30 Gy in 10 fractions, within 12 days (5 days a week). The psychophysiological approach before and after PCI was assessed by measurements of the auditory ERPs during a short memory performance using the digit-span Wechsler test. Components of ERP were recorded from 15 scalp electrodes. Additionally, symptomatology of depression and anxiety were assessed using Zung Self-Rating Depression Scale and Spielberger Anxiety Inventory, respectively, for pre- and post-PCI.
No significant difference was noticed pre- and post-radiotherapy of all particular level of psychophysiological analysis concerning both the latencies and the amplitudes of ERPs auditory components P50, N100, P300 and N400 (P > 0.05, Wilcoxon signed test). Additionally, no changes were found with regard to behavioral performance (memory recall), depression symptomatology and state anxiety, according to pre- and post-radiation measurements. However, the self-reported depression symptomatology showed that the patients presented moderate depression.
No short-term psychophysiological neurotoxicity was detected with this PCI schedule using these instruments, lending additional support to evidence suggesting the benefit of this certain PCI schedule for patients with SCLC.
本研究的目的是表明，在短期记忆测试期间，某种预防性适用的辐射是否会影响认知，特别是听觉事件相关电位（ERP）的特定认知成分P50、N100、P300和N400。
11例小细胞肺癌（SCLC）患者，在肺部化疗和根治性放疗后疾病呈现完全缓解，被规定使用6 MeV直线加速器接受预防性颅脑照射（PCI）。剂量方案包括在12天内（每周5天）分10次给予总剂量达30 Gy。在使用数字广度韦氏测试进行短期记忆表现期间，通过测量听觉ERP来评估PCI前后的心理生理学方法。从15个头皮电极记录ERP成分。此外，分别使用zung自评抑郁量表和斯皮尔伯格焦虑量表评估PCI前后的抑郁和焦虑症状。
在所有特定水平的心理生理学分析中，放疗前后关于ERP听觉成分P50、N100、P300和N400的潜伏期和波幅均未发现显著差异（P>0.05，Wilcoxon符号秩检验）。此外，根据放疗前后的测量，在行为表现（记忆回忆）、抑郁症状和状态焦虑方面未发现变化。然而，自我报告的抑郁症状表明患者呈现中度抑郁。
使用这些仪器，该PCI方案未检测到短期心理生理学神经毒性，这为表明该特定PCI方案对SCLC患者有益的证据提供了额外支持。
