Hemminki K, Li X, Mutanen P
Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.
Eur J Cancer Prev. 2001 Feb;10(1):83-9. doi: 10.1097/00008469-200102000-00010.
The Swedish Family-Cancer Database was used to analyse familial relationships in mothers and daughters with invasive and in situ cervical cancers by histological type during the years 1958-1996, including a total of 21,727 and 191,081 cases, respectively. Familial standardized incidence ratios (SIRs) were calculated separately for mothers and daughters and for invasive and in situ squamous cell carcinoma (SCC) and adenocarcinoma. Familial risks were about 2.0 in invasive SCC and less in in situ SCC. Limited analyses could be carried out on adenocarcinoma because the number of cases was small. However, familial risks were not much smaller in families where only SCC was diagnosed compared with those where both SCC and adenocarcinoma were present. A comparison of cancers between mothers and daughters showed an association between cervical cancer and SCC of skin, and between cervical cancer and smoking-related cancers. The familial risks were unaffected in Poisson regression analysis on many possible intervening variables. The data suggest that host factors modulate an individual's response to human papillomavirus infections.
瑞典家庭癌症数据库用于分析1958年至1996年间患有浸润性和原位宫颈癌的母女之间按组织学类型划分的家族关系，其中浸润性宫颈癌和原位宫颈癌病例数分别为21727例和191081例。分别计算了母亲和女儿以及浸润性和原位鳞状细胞癌（SCC）及腺癌的家族标准化发病率（SIR）。浸润性SCC的家族风险约为2.0，原位SCC的家族风险较低。由于腺癌病例数较少，因此对腺癌只能进行有限的分析。然而，与同时诊断出SCC和腺癌的家庭相比，仅诊断出SCC的家庭的家族风险并没有小太多。母女之间癌症的比较显示，宫颈癌与皮肤SCC之间以及宫颈癌与吸烟相关癌症之间存在关联。在对许多可能的干预变量进行的泊松回归分析中，家族风险不受影响。数据表明宿主因素调节个体对人乳头瘤病毒感染的反应。
