Auxilia S T, Hill P B, Thoday K L
Department of Veterinary Clinical Studies, The Royal Dick School of Veterinary Studies, The University of Edinburgh, The Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian.
J Small Anim Pract. 2001 Feb;42(2):82-7. doi: 10.1111/j.1748-5827.2001.tb01998.x.
The records of six dogs in which a diagnosis of symmetrical lupoid onychodystrophy (SLO) had been made were examined retrospectively. The age at onset ranged from six months to eight years. All the dogs had been presented with onycholysis, onychomadesis, onychalgia and onychodystrophy. The diagnosis of SLO was confirmed in all cases by histological examination. Histological features were similar in all cases and included hydropic degeneration of the basal cell layer, pigmentary incontinence and a cell-rich interface dermatitis. Response (defined as good, partial or failure) to various therapies was compared. Treatments (as initial therapy or following previous treatment failure) included essential fatty acids (EFA) (three cases), a combination of tetracycline and nicotinamide (four cases) and azathioprine and/or prednisolone (one case each). EFA therapy resulted in one good response, one partial and one failure, tetracycline and nicotinamide in two good responses, one partial and one failure, and azathioprine and/or prednisolone in one good and one partial response. Although all treatments were successful in some cases, none was universally effective.
对六只已确诊为对称性类狼疮甲营养不良（SLO）的犬只记录进行了回顾性研究。发病年龄从6个月至8岁不等。所有犬只均出现甲剥离、甲脱落、甲疼痛和甲营养不良症状。所有病例均通过组织学检查确诊为SLO。所有病例的组织学特征相似，包括基底细胞层的水样变性、色素失禁和富含细胞的界面性皮炎。比较了各种治疗方法的反应（定义为良好、部分有效或无效）。治疗方法（作为初始治疗或先前治疗失败后的治疗）包括必需脂肪酸（EFA）（3例）、四环素和烟酰胺联合使用（4例）以及硫唑嘌呤和/或泼尼松龙（各1例）。EFA治疗产生1例良好反应、1例部分有效和1例无效，四环素和烟酰胺治疗产生2例良好反应、1例部分有效和1例无效，硫唑嘌呤和/或泼尼松龙治疗产生1例良好反应和1例部分有效。尽管所有治疗方法在某些病例中都取得了成功，但没有一种方法是普遍有效的。
