对大鼠下丘脑内给药后肾上腺素引起的心血管变化。
Adrenaline-induced cardiovascular changes after intrahypothalamic administration to rats.
作者信息
Struyker Boudier H A, Bekers A D
出版信息
Eur J Pharmacol. 1975 Mar;31(1):153-5. doi: 10.1016/0014-2999(75)90088-6.
PMID:1126374
Abstract
Adrenaline caused a decrease in arterial blood pressure and heart rate when injected into the anterior thalamic region of rats. The size and the duration of these effects depended upon the dose of adrenaline injected. Adrenaline is 10 times more potent than noradrenaline in inducing these intrahypothalamic effects on cardiovascular parameters. These data support the concept of the relevance of adrenaline receptors in central autonomic regulation.
摘要
将肾上腺素注入大鼠丘脑前部区域时，会导致动脉血压和心率下降。这些效应的大小和持续时间取决于所注射肾上腺素的剂量。在对下丘脑内心血管参数产生这些效应方面，肾上腺素的效力比去甲肾上腺素强10倍。这些数据支持了肾上腺素受体在中枢自主调节中具有相关性的概念。
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