Tapp W N, Holloway F A
Psychopharmacology (Berl). 1979 May 25;63(2):193-4. doi: 10.1007/BF00429701.
Circadian variations in alpha-methyl-p-tyrosine's (alpha MT) disruption of active avoidance acquisition were studied, alpha MT administered between 11.0 and 13.00 h, 17.00 and 19.00 h and 23.00 and 01.00 h impaired learning, but alpha MT administered between 05.00 and 07.00 h did not impair learning. The time of alpha MT ineffectiveness corresponds with the reported circadian peak in brain catecholamines, suggesting that the circadian susceptibility rhythm of alpha MT depends upon circadian fluctuations of brain catecholamines.
研究了α-甲基对酪氨酸（αMT）对主动回避学习获得的干扰的昼夜变化。在11:00至13:00、17:00至19:00以及23:00至01:00给予αMT会损害学习，但在05:00至07:00给予αMT则不会损害学习。αMT无效的时间与所报道的脑儿茶酚胺昼夜峰值相对应，这表明αMT的昼夜易感性节律取决于脑儿茶酚胺的昼夜波动。
