乙基（甲基）二氧杂环丙烷作为一种在非碱性无水条件下将亚磷酸核苷氧化为磷酸的高效试剂。
Ethyl(methyl)dioxirane as an efficient reagent for the oxidation of nucleoside phosphites into phosphates under nonbasic anhydrous conditions.
作者信息
Kataoka M, Hattori A, Okino S, Hyodo M, Asano M, Kawai R, Hayakawa Y
机构信息
Laboratory of Bioorganic Chemistry, Graduate School of Human Informatics, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
出版信息
Org Lett. 2001 Mar 22;3(6):815-8. doi: 10.1021/ol000364w.
PMID:11263889
Abstract
A convenient method for the oxidation of nucleoside phosphites into phosphates under nonbasic and nonaqueous conditions using commercially available ethyl(methyl)dioxirane has been developed. This oxidation is effective with both N-protected and N-unprotected strategies.
摘要
已经开发出一种使用市售的乙基（甲基）二氧杂环丙烷在非碱性和非水条件下将亚磷酸核苷氧化为磷酸酯的简便方法。这种氧化对于N-保护和N-未保护策略均有效。
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