Berkelhamer S, Borock E, Elsen C, Englund J, Johnson D
Children's Hospital and Regional Medical Center, University of Washington, Seattle, WA, USA.
Clin Infect Dis. 2001 Apr 1;32(7):1090-4. doi: 10.1086/319591. Epub 2001 Mar 19.
Children infected with human immunodeficiency virus (HIV) often lose their vaccine-induced antibody to measles virus. Before highly active antiretroviral therapy (HAART), an additional immunization against measles infrequently resulted in protective antibodies. The antibody response to an additional measles-mumps-rubella (MMR) vaccination was compared in 28 HIV-infected children who lacked protective antibody to measles virus and were undergoing HAART or non-HAART regimens. Serostatus was measured by automated enzyme-linked immunoassay. Nine (64.3%) of 14 children undergoing HAART, compared with 3 (21.4%) of 14 in the non-HAART group, had antibody to measles virus after the additional vaccination with MMR (P=.027). The groups showed no significant difference in CD4 cell values. Ten of 14 HAART patients had undetectable levels of HIV. The mean HIV load for the HAART group was 27,700 copies/mL (median, <400 copies/mL); for the non-HAART group, it was 86,000 copies/mL (median, 9000 copies/mL). Thus, HAART improves the response to an additional MMR vaccination, which is consistent with immune system reconstitution.
感染人类免疫缺陷病毒（HIV）的儿童通常会失去疫苗诱导产生的麻疹病毒抗体。在高效抗逆转录病毒治疗（HAART）出现之前，额外接种一剂麻疹疫苗很少能产生保护性抗体。对28名缺乏麻疹病毒保护性抗体且正在接受HAART或非HAART治疗方案的HIV感染儿童，比较了他们对额外接种一剂麻疹-腮腺炎-风疹（MMR）疫苗的抗体反应。通过自动酶联免疫测定法检测血清状态。接受HAART治疗的14名儿童中有9名（64.3%）在额外接种MMR疫苗后产生了麻疹病毒抗体，相比之下，非HAART组的14名儿童中有3名（21.4%）产生了抗体（P = 0.027）。两组的CD4细胞值无显著差异。接受HAART治疗的14名患者中有10名HIV检测不到。HAART组的平均HIV载量为27,700拷贝/毫升（中位数，<400拷贝/毫升）；非HAART组为86,000拷贝/毫升（中位数，9000拷贝/毫升）。因此，HAART可改善对额外接种MMR疫苗的反应，这与免疫系统重建是一致的。
