慢性免疫性血小板减少性紫癜患者体内针对α(IIb)β(3)的自身抗体主要与α(IIb)上的表位结合。
Autoantibodies to alpha(IIb)beta(3) in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on alpha(IIb).
作者信息
McMillan R, Lopez-Dee J, Loftus J C
机构信息
Department of Molecular and Experimental Medicine, Room 215, The Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Blood. 2001 Apr 1;97(7):2171-2. doi: 10.1182/blood.v97.7.2171.
Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disease caused by platelet destruction resulting from autoantibodies against platelet surface proteins, particularly platelet glycoprotein IIb/IIIa (alpha(IIb)beta(3)). To localize the auto-epitopes on platelet alpha(IIb)beta(3), the binding of autoantibodies to Chinese hamster ovary (CHO) cells expressing either alpha(IIb)beta(3) or alpha(v)beta(3) was studied. Thirteen of 14 ITP autoantibodies bound only to CHO cells expressing alpha(IIb)beta(3). Because these 2 integrins have the same beta chain (beta(3)), these results show that most epitopes in chronic ITP are dependent on the presence of glycoprotein alpha(IIb.) (Blood. 2001;97:2171-2172)
慢性免疫性血小板减少性紫癜（ITP）是一种自身免疫性疾病，由针对血小板表面蛋白，特别是血小板糖蛋白IIb/IIIa（α(IIb)β(3)）的自身抗体导致血小板破坏引起。为了定位血小板α(IIb)β(3)上的自身表位，研究了自身抗体与表达α(IIb)β(3)或α(v)β(3)的中国仓鼠卵巢（CHO）细胞的结合情况。14份ITP自身抗体中有13份仅与表达α(IIb)β(3)的CHO细胞结合。由于这两种整合素具有相同的β链（β(3)），这些结果表明慢性ITP中的大多数表位依赖于糖蛋白α(IIb)的存在。（《血液》。2001年；97:2171 - 2172）
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