含氟药物的代谢
Metabolism of fluorine-containing drugs.
作者信息
Park B K, Kitteringham N R, O'Neill P M
机构信息
Department of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom.
出版信息
Annu Rev Pharmacol Toxicol. 2001;41:443-70. doi: 10.1146/annurev.pharmtox.41.1.443.
Abstract
This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.
摘要
本文综述了含氟药物代谢的现有知识。从化学结构以及药物代谢和药物毒性的基本概念方面，讨论了氟取代在药物设计中的战略价值。
Zotero 插件