Surgenor D M, Mierzwa B D
Fed Proc. 1975 May;34(6):1518-21.
Artificial blood will become important to the extent that it is safer, more effective, more economical, and more readily available than natural substances. If physicians would accept blood substitutes, their use might help to eliminate prevailing shortages of blood and increasing needs for plasma. The high demand for albumin, one of the safest biologics known, is pushing the requirement for plasma to higher levels every year. The albumin situation illustrates both the value placed on hemotherapeutic agents of proven safety and the problem of mobilizing sufficient blood resources for their production. The solutions to this problem and others addressed by the National Blood Policy will involve both scientific efforts and improvements in the operation and organization of blood service systems. Thus, the search for blood and plasma substitutes must be viewed as just one of a set of management and scientific approaches to meeting the need for safe, effective hemotherapuetic agents.
人造血液将在其比天然物质更安全、更有效、更经济且更容易获得的程度上变得重要。如果医生接受血液替代品,它们的使用可能有助于消除普遍存在的血液短缺以及对血浆不断增长的需求。对白蛋白(已知最安全的生物制品之一)的高需求正将每年对血浆的需求推向更高水平。白蛋白的情况既说明了对已证实安全的血液治疗剂的重视,也说明了为其生产调动足够血液资源的问题。国家血液政策所解决的这个问题及其他问题的解决方案将涉及科学努力以及血液服务系统运营和组织方面的改进。因此,寻找血液和血浆替代品必须被视为满足对安全、有效的血液治疗剂需求的一系列管理和科学方法之一。