Baris S, Karakaya D, Aykent R, Kirdar K, Sagkan O, Tür A
Department of Anesthesiology, Ondokuz Mayis University, Samsun, Turkey.
Can J Cardiol. 2001 Mar;17(3):277-81.
To compare the hemodynamic and sedative effects of midazolam - with or without fentanyl combination - with placebo in coronary angiography.
Prospective, double-blind, randomized study.
University medical centre.
All patients undergoing coronary angiography.
Demographic data, hemodynamic variables, sedation and anxiety scores, amnesia, patient and cardiologist satisfaction, and adverse effects were evaluated and compared among coronary angiography patients taking midazolam, midazolam and fentanyl, or placebo before the procedure.
Ninety patients scheduled for coronary angiography were randomly assigned into three groups: a midazolam-placebo group (group MP), a midazolam-fentanyl group (group MF) and a placebo group (group P). Hemodynamic stability was better in each sedation group (groups MP and MF) than in group P. Sedation scores, anxiolysis, and patient and cardiologist satisfaction were not different between the sedation groups.
Both techniques of conscious sedation - midazolam and midazolam with fentanyl - are satisfactory for coronary angiography where hemodynamic stability and patient cooperation are required. In such procedures, local anesthesia without sedation may lead to hypertension and increase overall morbidity.
比较咪达唑仑（联合或不联合芬太尼）与安慰剂在冠状动脉造影术中的血流动力学及镇静效果。
前瞻性、双盲、随机研究。
大学医学中心。
所有接受冠状动脉造影术的患者。
对冠状动脉造影术前服用咪达唑仑、咪达唑仑与芬太尼或安慰剂的患者，评估并比较其人口统计学数据、血流动力学变量、镇静及焦虑评分、遗忘情况、患者及心脏病专家满意度以及不良反应。
90例计划进行冠状动脉造影术的患者被随机分为三组：咪达唑仑-安慰剂组（MP组）、咪达唑仑-芬太尼组（MF组）和安慰剂组（P组）。各镇静组（MP组和MF组）的血流动力学稳定性均优于P组。镇静组之间的镇静评分、抗焦虑效果、患者及心脏病专家满意度无差异。
对于需要血流动力学稳定和患者配合的冠状动脉造影术，咪达唑仑及咪达唑仑联合芬太尼这两种清醒镇静技术均令人满意。在此类手术中，未使用镇静的局部麻醉可能导致高血压并增加总体发病率。
